Publications

Schlacher K (2019) Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics, JCB , Published online: 19 February 2019

http://jcb.rupress.org/content/early/2019/02/15/jcb.201901050

Schlacher K (2018) A new road to cancer-drug resistance, Nature , Published online: 31 October 2018

https://www.nature.com/articles/d41586-018-07188-1

Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K (2018) p53 suppresses mutagenic RAD52 and POLθ pathways by orchestrating DNA replication restart homeostasis. eLife

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832412/

<<Faculty of 1000 «very good>>

“Insight” preview in eLife (2018)

Roy, S.,J.W. Luzwick, K. Schlacher (2018). SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. JCB

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881507/

Spotlight in JCB (2018)

Schlacher, K.(2017).PARPi focuses the spotlight on replication fork protection in cancer. Nature Cell Biology

https://www.ncbi.nlm.nih.gov/pubmed/29087384

 

Tian, Y., Shen, X., Wang, R., Klages-Mundt, N., Lynn, E.J., Martin, S.K., Ye, Y., Gao, M., Chen, J., Schlacher, K.,Li, L.(2017).Constitutive role of the Fanconi anemia D2 gene in the replication stress response. Journal of Biological Chemistry,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724005/

Schlacher, K., Wu, H. and *Jasin M. (2012). A Novel Replication Fork Protection Pathway connects Fanconi Anemia Tumor Suppressor to RAD51-BRCA1/2. Cancer Cell http://www.ncbi.nlm.nih.gov/pubmed/22789542

Siaud, N., Barbera M, Egashira, A., Lam I., Christ, N. Schlacher, K. Xia B., and Jasin, M. (2011). Plasticity of BRCA2 Function in Homologous Recombination. PLOS Genet.

http://www.ncbi.nlm.nih.gov/pubmed/22194698

<<Faculty of 1000 «must read»

Schlacher, K., Christ, N., Siaud, N., Egashira, A., Wu, H., and *Jasin, M. (2011). Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11. Cell, 

https://www.ncbi.nlm.nih.gov/pubmed/21565612                                  

<<Faculty of 1000 «must read»

Research Highlight in Nature Revs. Mol. Cell Biol.

Schlacher, K., and Goodman, M.F. (2007). Lessons from 50 years of SOS DNA-damage-induced mutagenesis. Nature Revs. Mol. Cell Biol.

http://www.ncbi.nlm.nih.gov/pubmed/17551516


Schlacher, K., Cox, M.M., Woodgate, R., Goodman, M.F. (2006). RecA acts in trans to allow replication of damaged DNA. Nature    

http://www.ncbi.nlm.nih.gov/pubmed/16929290

 <<Faculty of 1000 «recommended»

Schlacher, K., Jiang, Q., Woodgate, R., Goodman, M.F. (2006). Purification and Characterization of Escherichia Coli DNA Polymerase V. Meth. of Enz.

http://www.ncbi.nlm.nih.gov/pubmed/16793381

Schlacher, K., Pham, P., Cox, M. M., Goodman, M. F. (2006). Roles of DNA Polymerase V and RecA Protein in SOS Damage-Induced Mutation. Chemical Rev.

http://www.ncbi.nlm.nih.gov/pubmed/16464012

Schlacher, K., Leslie, K., Wyman, C., Woodgate, R., Cox, M. M., Goodman, M. F. (2005). DNA polymerase V and RecA protein, a minimal mutasome. Mol. Cell

http://www.ncbi.nlm.nih.gov/pubmed/15721259

News and views in Nature Struct. & Mol. Biol.  (2005),

Collaborative publications:

Gadhikar MA, Zhang J, Shen L., Schlacher K, Frederick MJ, Myers JN. (2018).  CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Research

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811346/

Xu S., Wu X., Wu L., Castillo A., Liu J., Atkinson E., Paul A., Su D., Schlacher K.,Komatsu Y., You MJ., Wang B.(2017).Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes & Development,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588928/

Liu, W., Zhou, M., Li, Z., Li, H., Polaczek, P., Dai, H., Wu, Q., Liu, C., Karanja, K., Popuri, V., Shan., S., Schlacher., K., Zheng, L., Campbell, J., Shen, B. (2016). Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EbioMedicine,

http://www.ncbi.nlm.nih.gov/pubmed/27211550

Guo, C., Kumagai, A., Schlacher, K., Shevchenko, A., Shevchenko, A. and Dunphy, W.G. (2015). Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication. Mol. Cell

http://www.ncbi.nlm.nih.gov/pubmed/25557548

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